PROCESS FOR PREPARING BETA-HYDROXY AMINO ACID.

摘要

Process for mfg. beta hydroxy amino acid, e.g. DL serine, threonine, beta hydroxyvaline or beta hydroxyphenylalanine, on an industrial scale with hardly any side prods. is effected by adsorbing aziridine-2-carboxylic acids of formula (I) (R1= hydrogen or methyl, (un)substd. phenyl or pyridyl gp.; R2= methyl gp. or hydrogen; X=-CO2H, CO2M (M=alkali metal or alkali earth metal), -CO2R3 (R3=1-5C lower alkyl or aralkyl gp.) -CONH2 or -CN, but is not -CO2H or CO2M when both R1 and R2 are hydrogen) or its deriv. on strongly acidic cation exchange resin, pref. H type resin, and heating in the presence of water for 1-100 hr. at 40-120 deg.C, pref. 2-50 hr. at 50-100 deg.C.