发明名称 |
PROCEDE POUR PREPARER HEXAHYDROINDAZOLISOQUINOLENES-6-SUBSTITUES |
摘要 |
Hexahydroindazolo or hexahydroisoindolo isoquinolines of the formula <CHEM> wherein R is H, alkyl, allyl or benzyl; R<1> and R<2> are independently H, OH or alkoxy, with the limitation that when either R<1> or R<2> is OH, then the other R<1> or R<2> can not be alkoxy; Z is <CHEM> R<3> is H or -@-(C1-C2)alkyl; and the dotted line represents the presence of one double bond at either 7a-10a or 7a-8, having dopamine agonist and dopamine antagonist activity, are described herein. The compounds are prepared by reacting the the corresponding 8-dimethylaminomethylene derivative with a substituted amino. Novel intermediates are also disclosed. |
申请公布号 |
RO82502(A) |
申请公布日期 |
1983.09.26 |
申请号 |
RO19820106957 |
申请日期 |
1982.03.18 |
申请人 |
ELI LILLY AND CO,US |
发明人 |
KORNFELD,EDMUND C.,US;BACH,NICHILAS J.,US;TITUS,ROBERT S.,US |
分类号 |
C07D471/04;A61K31/47;A61K31/473;A61K31/4745;A61P9/12;A61P25/00;A61P25/08;A61P25/16;C07D217/14;C07D217/16;C07D221/14;C07D471/06 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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