摘要 |
Dihydropyridines of the formula:- …<CHEM>… and their pharmaceutically acceptable acid addition salts… wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-;… R is aryl or heteroaryl;… R<1> and R<2> are each independently C1-C4 alkyl or 2-methoxyethyl; and… R<3> is hydrogen, C1-C4 alkyl, 2-(C1-C4 alkoxyl) ethyl, cyclopropylmethyl, benzyl, or -(CH2)mCOR<4> where m is 1, 2 or 3 and R<4> is hydroxy, C1-C4 alkoxy or - NR<R>5<6> where R<5> and R<6> are each independently hydrogen or C1-C4 alkyl, pharmaceutical compositions containing them, and processes for their production. …<??>The compounds are particularly useful in the treatment or prevention of a variety of cardiac conditions, e.g, angina pectoris. |