| 摘要 |
<p>A new istamycin A derivative called di-N6', O3-demethylistamycin A exhibits a high antibacterial activity against various bacteria, particularly Pseudomonas aeruginosa. This compound can be prepared by selective acylation of the methylamino group at the 4-position of 1,2',6'-tri-N-protected N4-deglycyl-di-N6', O3-demethylistamycin A with glycine or an N-protected derivative thereof, followed by N-deprotection.</p> |
