Pyridine derivatives.

摘要

Compounds of formula (1):-
<Chemistry id="chema01" num="0001"><Image id="ia01" he="32" wi="28" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and pharmaceutically acceptable salts thereof, where
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sup>1</Sup> and R<Sup>2</Sup> are the same or different and are C<Sub>1-6</Sub> alkyl or with the nitrogen atom to which they are attached form a pyrrolidino or piperidino group;</ListItem><ListItem>R<Sup>3</Sup> is C<Sub>1-4</Sub> alkylene;</ListItem><ListItem>W is a group -XYCH<Sub>2</Sub>CH<Sub>2</Sub>NHR<Sup>4</Sup> in which</ListItem><ListItem>Y is methylene or sulphur:</ListItem><ListItem>X is methylene or oxygen, provided that it is methylene when Y is sulphur, and</ListItem><ListItem>R<Sup>4</Sup> is a group of formula (2):-</ListItem></UnorderedLists><Chemistry id="chema02" num="0002"><Image id="ia02" he="25" wi="32" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where
<UnorderedLists id="ula02" listStyle="none"><ListItem>R<Sup>5</Sup> is NCN, NNO<Sub>2</Sub>, NH or CHNO<Sub>2</Sub> and R<Sup>6</Sup> is hydrogen, hydroxy, amino, C<Sub>1-6</Sub> alkyl, C<Sub>2-4</Sub> alkynyl; or R<Sup>4</Sup> is a group of formula (3):-</ListItem></UnorderedLists><Chemistry id="chema03" num="0003"><Image id="ia03" he="27" wi="50" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where
<UnorderedLists id="ula03" listStyle="none"><ListItem>R<Sup>7</Sup> is a covalent bond or methylene or ethane-1, 2-diyl optionally substituted with one C<Sub>1-6</Sub> alkyl group or a <!-- EPO <DP n="2"> -->second C<Sub>1-6</Sub> alkyl group or a phenyl (C<Sub>1-6</Sub> alkyl) group, or a group of formula (4):-
<Chemistry id="chema04" num="0004"><Image id="ia04" he="27" wi="48" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem></UnorderedLists>where
<UnorderedLists id="ula04" listStyle="none"><ListItem>R<Sup>8</Sup> is hydrogen; C<Sub>1-6</Sub> alkyl, optionally substituted phenyl or phenyl (C<Sub>1-6</Sub> alkyl), (the substituents being one or more C<Sub>1-6</Sub> alkyl or C<Sub>1-6</Sub> alkoxy groups or halogen atoms or a methylenedioxo group), or optionally substituted furanyl- or thienyl- or pyridyl(C<Sub>1-6</Sub> alkyl) (the substituents being one or more C<Sub>1-6</Sub> alkyl or C<Sub>1-6</Sub> alkoxy groups); and R<Sup>9</Sup> is hydrogen, C<Sub>1-6</Sub> alkyl or benzyl,</ListItem><ListItem>or W is Y<Sup>1</Sup>R<Sup>10</Sup> where</ListItem><ListItem>Y<Sup>1</Sup> is (CH<Sub>2</Sub>), where a is from 3 to 6 or (CH<Sub>2</Sub>)<Sub>b</Sub>S(CH<Sub>2</Sub>)<Sub>d</Sub> where b and d are the same or different and are from 1 to 3 or O(CH<Sub>2</Sub>)<Sub>f</Sub> where f is from 2 to 5 and</ListItem><ListItem>R<Sup>10</Sup> is a group of formula (5):-
<Chemistry id="chema05" num="0005"><Image id="ia05" he="23" wi="33" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem></UnorderedLists>where
<UnorderedLists id="ula05" listStyle="none"><ListItem>R" is cyano, carbamoyl, ureido, hydroxy, C<Sub>1-6</Sub> alkoxy, C<Sub>1-6</Sub> alkanoyl, C<Sub>1-6</Sub> alkanoylamino, arylsulphamoyl, aralkanoyl, carboxymethyl or a group of formula (6):-
<Chemistry id="chema06" num="0006"><Image id="ia06" he="14" wi="19" file="IMGA0006.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem></UnorderedLists>where
<UnorderedLists id="ula06" listStyle="none"><ListItem>R" is C<Sub>1-6</Sub> alkyl, haloC<Sub>1-6</Sub>alkyl, optionally substituted phenyl, amino, mono or di(C<Sub>1-6</Sub>)alkanoylamino, arylamino or arylalkanoylamino;</ListItem><ListItem>R<Sup>12</Sup> is hydrogen C<Sub>1-6</Sub> alkyl C<Sub>2-6</Sub> alkanoyl, C<Sub>2-6</Sub> alkenyl, C<Sub>2-6</Sub> alkynyl, cyano; or</ListItem><ListItem>R<Sup>10</Sup> is a group of formula -CONHR<Sup>14</Sup> where R<Sup>14</Sup> is hydrogen, C<Sub>1-6</Sub> alkyl, hydroxy or sulfamoyl.</ListItem></UnorderedLists>