发明名称 |
PROCESS FOR PREPARING IMIDAZOLE DERIVATIVE |
摘要 |
The present invention relates to a novel process for preparing 4-¢(2-aminoethyl)thiomethyl!-5-methyl imidazole of the formula I and its acid addition salts, characterized as a process for preparing 4-¢(2-aminoethyl)thiomethyl!-5-methyl imidazole of the formula and its acid addition salts, characterized in that a compound of the formula wherein M represents hydrogen or an alkali metal, is reacted with a 2-haloethylamine, wherein halo represents chloro or bromo, in a system consisting of an aqueous solution or a strong base and of an organic phase, at room temperature in the presence of quaternary ammonium or quaternary phosphonium salts as phase transfer catalysts. |
申请公布号 |
CA1154023(A) |
申请公布日期 |
1983.09.20 |
申请号 |
CA19810368285 |
申请日期 |
1981.01.12 |
申请人 |
LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O |
发明人 |
JENKO, BRANKO;LANGOF, IGOR |
分类号 |
C07D233/64;B01J31/00;B01J31/02;C07B61/00;C07D;C07D233/54;C07D233/61 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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