Method for preparing salts of 6-chloropurine

摘要

There is described a novel method for preparing and isolating novel salts of 6-chloropurine and strong acids. According to the method hypoxanthine is reacted with phosphorus oxychloride in the presence of an organic base to form 6-chloropurine, a solvent is added to the reaction mixture and the latter is reacted with a strong acid to form a 6-chloropurine salt which is then isolated. In a preferred embodiment 6-chloropurine is freed from the salt with water, preferably in the presence of a base. In another preferred embodiment the 6-chloropurine is aminated with various amines.