| 摘要 |
Purified enzyme (I), analogous to human leucocyte pepsin, has the following properties (1) mol. wt. 35000-41000; (2) isoelectric point pH 2.5-3.5; (3) max. absorbence at 278 nm.; (4) positive ninhydrin reaction; (5) easily soluble in water but insoluble in ether and chloroform, and (6) is a white powder with antiallergic and antitumour activities and activity against immuno-complex disorders. - (I) administered orally, rectally or by inhalation, pref. at 1-1000, esp. 5-500, mg. per day. - (I) suppresses prodn. of IgE so is useful for treating e.g. bronchial asthma, urticaria, dermatitis, etc. It also inhibits immuno-complex disorders such as thyroiditis and nephritis and has activity against e.g. L1210 and P388 leukaemia and MX-1 human breast cancer. Since (I) is of human origin, there are no serious risks of anaphylactic reactions and in mice, parenteral doses of 2 g. (I) per kg. caused no toxic symptoms.
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