| 摘要 |
NEW MATERIAL:A thiophenol derivative shown by the formulaI(R1 is lower alkyl; R2 is a group caused by a reaction with a mercapto group; X is halogen). EXAMPLE:N-( Ethoxycarbonyl )-N- 4-( 2-hydroxyethyl )-1-piperazinyl carbomethyl- 2-(1-methyl-1-ethoxy)methylthio-5-chloroaniline. USE:Having analgesic action, expected as a remedy for remedying. PROCESS:A compound (novel compound) shown by the formula II is reacted with a compound such as ethyl vinyl ether, etc. to react with a mercapto group, to give a compound shown by the formula III, which is reacted with a halogenoacetic ester in the presence of a base to give a compound shown by the formula IV (R3 is as shown for R2). This compound is reacted with a compound such as piperazine ethanol, etc. shown by the formula V preferably in the presence of a catalytic amount of a base, to give a compound shown by the formulaI. |
