Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them.

摘要

The compounds of the present invention are compounds of the formula <CHEM> and the pharmaceutically acceptable esters and salts thereof wherein R<1> and R<2> independently are hydrogen or lower alkyl; the group <CHEM> is one of the structures II to VIII specified @ the description, one of R<3>, R<4> and R<5> is a group @ wherein Z is selected from Z<1> to Z<1><0> being as @@ in the description and the other of the groups R<3>, R<4> and R<5> are as also defined. The compounds are useful as @@hypertensive agents, in the treatment of congestive heart failure and glaucoma. Their preparation and pharmaceutical compositions are disclosed.