THIOXO-1H-BENZ(DE)ISOQUINOLINE-2(3H)- ACETIC ACID DERIVATIVES

摘要

AHP-7451 Herein disclosed are 1H-benz¢de!isoquinoline-2(3H)-acetic acid derivatives. The derivatives are characterized by being derived from 1,3-dioxo-1H-benz¢de!isoquin-oline-2H-acetic acid by replacing one of the oxygen atoms with sulfur and by optional substitution at position 6 with a phenylthio group. The derivatives inhibit lens aldose reductase in a diabetic subject.