FREMGANGSMAADE TIL FREMSTILLING AF ANTHRACYCLINGLYCOSIDANTIBIOTIKA BETEGNET MA 144-M1 OG MA 144-M2 ELLER IKKE TOKSISKE SYREADDITIONSSALTE ELLER KOMPLEKSER DERAF MED DESOXYRIBONUCLEINSYRE

摘要

New antitumor agents designated MA 144-M1 and MA 144-M2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.