摘要 |
<p>New antineoplastic glycosides, phyllanthostatin 1,2 and 3, of formula:<!-- EPO <DP n="2"> --><Chemistry id="chema01" num="0001"><Image id="ia01" he="40" wi="128" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><Chemistry id="chema02" num="0002"><Image id="ia02" he="43" wi="128" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><Chemistry id="chema03" num="0003"><Image id="ia03" he="36" wi="129" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.</p> |