FREMGANGSMAADE TIL FREMSTILLING AF BIFUNKTIONELT TVAERBUNDET INSULIN

摘要

1374562 Insulin derivatives; preparation BAYER AG 28 Feb 1973 [1 March 1972] 9727/73 Heading C2C The bifunctionally cross-linked insulins of partial Formula I in which X is a direct bond or a 1-15C aliphatic hydrocarbon chain of which one or more carbon atoms are optionally replaced by one or more heteroatoms and either carrying no substituents or carrying hydrophilic substituents are prepared by a sequence of reactions as exemplified in the following scheme (Y is a protecting group). The S-protected A-chain and B-chain derivatives are, e.g. the S-sulphonates. The products of partial Formula I are claimed per se in Specification 1,374,385.