发明名称 POMOLIC ACID DERIVATIVE
摘要 NEW MATERIAL:A compound of formulaI(R<1> is H, formula II; R<2> is H, lower alkyl, formula III, where, when R<1> is H, R<2> is formula III). EXAMPLE:Methyl 3beta-O- beta-D-glucopyranosyl-(1 2)-alpha-L-arabinopyranosyl -pomolate. USE:A preventive and curing agent for thrombosis, or a lipid metabolism improver. PREPARATION:For example, SHINA-HIIRAGI (Ilex Cornuta in Aquifoliaceae) is extracted with a polar solvent such as methanol, the extract is concentrated under reduced pressure to give the primary extract. The extract is treated with activated carbon, silica gel, or ion exchange resin to utilize the difference in adsorbability and affinity to isolate compounds of formula IV and V. When necessary, the compound of formula IV is esterified to give the compound of formulaIwhere R<2> is lower alkyl.
申请公布号 JPS58146600(A) 申请公布日期 1983.09.01
申请号 JP19820030283 申请日期 1982.02.25
申请人 OTSUKA SEIYAKU KK 发明人 NAKANISHI TSUTOMU;YONEDA KATANORI;MIURA IWAO
分类号 A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K36/18;A61P3/06;A61P7/02;A61P9/00;C07H15/256;C07J63/00 主分类号 A61K31/70
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