Tri-, tetra, and penta-peptides, their preparation and compositions containing them

摘要

The invention provides tri-, tetra- or penta-peptides of the general formula: <IMAGE> in which RCO is a fatty acid residue, R1 is hydroxyl, amino, alkoxy or benzyloxy, R2 and R4 (identical or different) represent hydrogen, carboxyl, alkoxycarbonyl or benzyloxycarbonyl or an optionally esterified N-carbonylglycyl or N-carbonyl-D-alanyl radical, it being impossible for R2 and R4 simultaneously to represent hydrogen, R3 is hydrogen, or represents a glycyl or D-alanyl residue (in which case, only one of the radicals R2 and R4 can represent an N-carbonylglycyl or N-carbonyl-D-alanyl radical), X is a sulphur atom or methylene, and m and n=1 or 2, it being understood that if X is methylene, m and n are different from 1, their salts, their preparation and compositions containing them: the compounds are useful as vaccine adjuvants or as non-specific stimulants of anti-infectious or anti-tumoral activity.