N-(6-((ACYLAMINOACYLAMINO OR AMINOACYLAMINO)PHENYL) 1,2-DIHYDRO-2-OXONICOTINYL)PENICILLIN COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM

摘要

Compounds which are N-[6-[(acylaminoacylamino or aminoacylamino) phenyl]-1,2- dihydro-2- oxonicotinyl]penicillins having the formula

and pharmaceutically acceptable salts thereof; have broad spectrum antibacterial utility. They can be produced by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)-phenyl]-1,2-dihydro-2-oxonicotinic acid, or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro--oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing the compounds, methods for treating infections using such compositions and the starting compounds are also disclosed.