VERFAHREN ZUR HERSTELLUNG VON CARNITINAMID

摘要

Process for the production of carnitine amide in the form of a chloride. The carnitine ethyl ester is obtained by reaction of 4-chloroacetoacetic acid ethyl ester with trimethyl amine and the subsequent hydrogenation is carried out with the help of a Pt/C catalyst. Such carnitine ethyl ester, without isolating it, is reacted with ammonia in an autoclave at -30 DEG to +10 DEG C. Everything is heated to 40 DEG to 80 DEG C. The mixture is stirred at such temperature at an ammoniac pressure of 8 to 24 atu. The product is filtered after cooling it to ambient temperature and counterbalancing the excess pressure. The product is then washed with alcohol and subsequently dried at 30 DEG to 50 DEG C. and at a pressure of 15 to 25 torr.