FORFARANDE FOR FRAMSTELLNING AV ANTIBIOTIKA AV CEFALOSPORINTYP.

摘要

1467217 Cephalosporins MEIJI SEIKA KAISHA Ltd 19 June 1975 [20 June 1974] 26071/75 Heading C2C The invention comprises novel antibiotic compounds (I) and (I1) wherein R1 is a phenyl group, a 2-thienyl group or a phenoxy group; R2 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may be substituted with a phenyl group, an alkoxy group having 1 to 4 carbon atoms or a halogen atom, or a phenyl group which may be substituted with one or two groups selected from a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R3 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may be substituted with a monoalkylamino group having 1 to 4 carbon atoms in the alkyl moiety thereof, a dialkylamino group having 1 to 4 carbon atoms in each alkyl moiety thereof, a halogen atom or a phenyl group which may be substituted with one to three groups selected from a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R4 represents an alkyl group having 1 to 4 carbon atoms; A has up to 15 carbon atoms and represents a straight or branched chain alkylene group, a straight or branched chain alkadienylene group or a phenylene group, and n is 0 or 1; or a salt thereof. They are made by reacting compounds (II) with compounds (III) or by reacting (III) with (IV) and acylating the 7-amino compound (V) obtained compounds (I) where n is 0, R1 is 2-thienyl and R2 is alkyl can, if desired, be decarboxylated to cleave the -COOR3 group to form (I1), or (V) may be decarboxylated and the compound obtained thereafter acylated with a 2-theinylacetic acid derivative to give (I1).