| 摘要 |
A pharmaceutical compn. with controlled release of active material in the intestinal tract was described. The compn, consisted of a tablet nucleus of active material with a coating resistant to gastric juices, and an outer layer of active material, which enabled a quick release of drug into the blood stream via the stomach and a high initial concn. in the blood. This high blood level is maintained by a further release of drug in the small intestine. A typical tablet comprised; 1) a nucleus of 4-(2-hydroxy-3-isopropylaminopropoxy) indole (I) 5, Na lauryl sulfate 2.5, Et cellulose 4.5, microcryst. cellulose 7.0, mannitol 27.5; and 2) gastric juiceinsol. layer of hydroxypropyl Me cellulose phthalate, etc.
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