Derivatives of benzo-1,2-thiazine-1,1-dioxide, a process for their preparation and pharmaceutical compositions containing the same.

摘要

Esters of 4-hydroxy-2-alkyl-3-aminocarboyl-2H-1,2-thiazine-1,1-dioxide having formula (I) <CHEM> where R stands for lower alkyl C1-C4; R1 stands for a linear or a branched alkyl bearing from 1 to 5 atoms of carbon and preferably ter-butyl; Ar stands for an aromatic or heteroaromatic residue bearing from 1 to 3 etheroatoms such as O, S, N, and preferably the residues 2-pyridyl, 2-thiazolyl; and their addition salts with pharmaceutically acceptable acids are endowed with a therapeutic index higher the one of the parent, not esterified compounds.