| 摘要 |
<p>NEW MATERIAL:A compound of formulaI(R<11>, R<12> are H, halogen; R<2> is H, lower alkyl; m is 1-3; R<3> is H, hydroxyl; R<4> is H, lower alkoxy; R<5> is H, acetoxy). EXAMPLE:7-{D(-)-alpha-[3-( 3,4-dihydroxybenzoyl )-3-( 3-hydroxypropyl)-1-ureido]- alpha-phenylacetamide}-3-( 1-methyl-1H-tetrazol-5-ylthiomethyl )-3-cephem-4-carboxylic acid. USE:An antibacterial with a wide range of antibacterial spectrum. PREPARATION:The reaction of 7-aminocephalosporin of formula II (R<6> is H, protecting group) such as 7-amino-3-( 1-methyl-1H-tetrazol-5-ylthiomethyl )-3- cephem-4-carboxylic acid with a compound of formula III gives the objective compound of formulaI.</p> |
