发明名称 |
PENTAPEPTIDES AS ANALGESICS |
摘要 |
Novel peptides of formula (I) X-Tyr-X2-Gly-Phe(4NO2)-Pro-NH2 (I) and salts thereof, wherein X is hydrogen or an amidino group and X2 is a radical selected from D-S-methylmethionyl and D-arginyl, have a selectively peripheral analgesic effect when administered to mammals. The compounds also exhibit antidiarrhoeal and antitussive activity and may thus be used in human or veterinary medicine for the relief or prevention of pain, for the treatment of diarrhoea or dysentery and for the suppression of cough. |
申请公布号 |
AU1115583(A) |
申请公布日期 |
1983.08.11 |
申请号 |
AU19830011155 |
申请日期 |
1983.02.04 |
申请人 |
WELLCOME FOUNDATION LTD., THE |
发明人 |
LAWRENCE ALFRED LOWE;TERENCE WILLIAM SMITH;SAMUEL WILKINSON |
分类号 |
C07K1/113;A61K38/00;A61P25/04;C07K7/06;C07K14/70 |
主分类号 |
C07K1/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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