PROCESS FOR PREPARING CEPHALOSPORIN ANTIBIOTICS

摘要

Cefuroxime alkanoyloxymethyl esters I (R = C1-4 alkyl) were prepd. for use as antibiotics. Thus, cefuroxime was stirred with K2CO3 and DMF, followed by the addn. of acetoxy methyl bromide to give I (R = CH3). I are more easily absorbed through the gastrointestinal tract than the parent cefuroxime and thus are suitable for oral administraction.