Aminocyclitol antibiotics, pharmaceutical compositions and method of using same

摘要

Aminocyclitol analogs of gentamicin C1, C2 and C1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an omega -amino- alpha -hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an omega -(N-benzyloxycarbonyl)amino- alpha -hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.