| 摘要 |
PURPOSE:To obtain an immunochemical measuring reagent having a high bonding rate of antigen and antibody and low adsorbtivity of interfering materials in blood serum and also having high measuring accuracy, by combining antigen or antibody with an amino radical of thermoplastic cellulose (derivatives) introduced the amino radical. CONSTITUTION:Epichlorohydrin, etc. is reacted to thermoplastic cellulose (a central part may be not hydrolyzed) obtained by hydrolyzing a granular or columnar form cellulose ester or thermoplastic cellulose derivatives such as cellulose ether, cellulose ester ether, etc. and amino radical is introduced by reacting amines such as NH4, NH2R, NHR2, NR3 etc. or polyamine etc. An immunochemical measuring reagent is obtained by combining an antigen (including hapten) having the amino radical, SH radical and radicals such as COOH, SO3H, etc. or an antibody with said amino radical. Particles having a higher bonding rate of the antigen and antibody than a conventional reagent and being easy of formation and handle, are made and the reagent having high measuring accuracy is obtained. |
