| 摘要 |
<p>Peptides of the formula X-A-Pro-Pro-Ile-Ser-B-C-Leu-D-E-F-G-W wherein X is H, a terminal N atom protecting group of acyl, aromatic urethane, aliphatic urethane, alkyl or aralkyl type, or a residue of a natural L-amino acid, the free amino group of the residue optionally being protected by a terminal N atom protecting group as aforesaid; A is a L-amino acid residue or a glycine residue; B is a neutral L-amino acid residue; C is a neutral L-amino acid residue or an acidic L-amino acid residue; D is a L-amino acid residue which contains in the side chain an alcoholic hydroxyl group; the latter may be free or protected by a usual protecting group for the hydroxy function, said protecting group being t-butyl, trityl, benzyl, 2,4-dichloro-benzyl, benzyloxycarbonyl, 2-bromobenzyloxycarbonyl t-butoxycarbonyl or lower acyl; E is a valence bond or a neutral L-amino acid residue; F is a valence bond or a L-amino acid residue; G is a valence bond or a neutral L-amino acid residue; W is OH, NH2, OR, NHR, NR2 or NH-NH-R'; R is a straight chain, branched chain or cyclic (including fused or bridged ring), substituted or unsubstituted C1C11 alkyl group, phenyl, or C6-C8 aralkyl; R' is H, any value which R may have, a straight chain, branched chain or cyclic aliphatic C1-C11 acyl group (optionally substituted by OH, NH2, or a halogen atom), a C3-C8 alkenyl group, an aromatic acyl group similarly optionally substituted, a straight chain, branched chain or cyclic aliphatic C3-C11 urethane type group or an aromatic urethane type group. Phamaceutically acceptable salts of these peptides are also provided, as are pharmaceutical compositions containing peptides or their salts. The peptides can be prepared by classical solution synthesis or by solid phase synthesis on polymeric supports.</p> |
