摘要 |
PURPOSE:An ophthalmic liquid solution, containing 2-(2-fluoro-4-biphenylyl)propionic acid and beta-or gamma-cyclodextrin or further a viscous agent, having greatly reduced irritant action, and stable for a long term without side effects. CONSTITUTION:The titled solution containing (A) 2-(2-fluoro-4-biphenylyl)propionic acid of the formula or a salt thereof and (B) beta-or gamma-cyclodextrin at 1:(0.5-1.5) molar ratio or further a viscous agent. The concentration of the component (A) in the solution is 0.001-2W/V%, and the pH of the solution is adjusted with a buffer agent to 5.0-8.0. In preparing the solution, the components (A) and (B), or a clathrate compound thereof, or a clathrate compound of the components (A) with (B) is dissolved in a water medium. The resultant solution is capable of solubilizing the component (A) in a high concentration, and therefore the inhibitory action on intraocular prostaglandins (PGs) and the mydriatic effect are more remarkable to give the marked effect on surgical operations, etc.
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