发明名称 |
9-Epi-mitomycin B and D compounds |
摘要 |
Mitomycin compounds of the general formula (I): <IMAGE> (I) wherein X is selected from an alkoxy group having 1 to 4 carbon atoms and amino group; and Z is selected from -OH, -OCONH2 and -OCO2C6H5 groups. The compounds of this formula may be used as starting materials for the preparation of various mitomycin compounds. When X is as hereinbefore defined and Z is -OCONH2, the compounds exhibit antibacterial activity and are of potential interest as medicaments. Preferred examples of the compounds are 9-Epi-mitomycin B and 9-epi-mitomycin D. The compounds of the formula (I) may be obtained from known mitomycin B or mitomycin D.
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申请公布号 |
US4395558(A) |
申请公布日期 |
1983.07.26 |
申请号 |
US19810323847 |
申请日期 |
1981.11.23 |
申请人 |
KYOWA HAKKO KOGYO KABUSHIKI KAISHA |
发明人 |
KASAI, MASAJI;SHIRAHATA, KUNIKATSU;KONO, MOTOMICHI |
分类号 |
A61K31/40;A61P31/04;C07D487/14;(IPC1-7):A61K31/40;C07D487/04 |
主分类号 |
A61K31/40 |
代理机构 |
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