| 摘要 |
NEW MATERIAL:A compound (salt) of formulaI(R<1> and R<6> are H or alcoholic residue; R<2> is H, lower alkyl, aryl lower alkyl or aryl; R<3> and R<5> are H, lower alkyl or aryl lower alkyl R<4> is H; R<4> and R<5> together with the adjacent N and C atoms may form a 5--6-membered heterocyclic ring). EXAMPLE:N-[alpha-(Dibenzylphosphono)benzyl]-L-alanyl-L-proline methyl ester. USE:A remedy for hypertension having improved inhibitory action on angiotensin converting enzymes. PROCESS:An N-phosphonomethylamino acid derivative of formula II is condensed with an amino acid derivative of formula III. |
