| 摘要 |
<p>Described herein are oxazolinoazetidinones of formula (I): (I) wherein R is hydrogen or a carboxylic acid protecting group and R1 is (a) hydrogen, C1-C4 alkyl or halo(C1-C4 alkyl); (b) a group R6 wherein R6 is phenyl or phenyl substituted by 1 or 2 groups selected from the group consisting of fluoro, chloro, bromo, iodo, nitro, cyano, C1-C4 alkyl, C1-C4 alkoxy, protected hydroxy, carbamyl, trifluoromethyl and methanesulfonamido; (c) a group of the formula R6(O)mCH2wherein m is 1 or 0 and R6 is as defined above (d) a group of the formula R6aCH2wherein R6a is cyclohexadienyl, 2furyl, 2-thienyl, or 3-thienyl; or (e) a group of the formula -COOR wherein R is as defined above. These compounds are prepared by cyclising a chloroazetidinone compound of formula (II): (II) wherein R and R1 are as defined above. The aforesaid oxazolinoazetidinones of formula (I) are useful intermediates for the synthesis of oxygen analogues of penicillins.</p> |
