| 摘要 |
<p>Prepn. of a 1-arylethanol deriv. (1-(4-amino-3,5-dichlorophenyl)- 2-tert-butylaminoethanol) consists of reaction of alpha-bromo-4-nitr,5-dichloroacetophenone with ammonia in ethanol at 5-15 deg.C, followed by treatment with a cationic terbutyl system, esp. hydrogen chloride gas and isobutylene, to yield 1-(4-nitro-3,5-dichloro)-2-terciolentyl (sic) -acetophenone, which undergoes successive reduction with a mixt. of chlorhydrin iron and sodium borohydride. - Prod. is useful as a bronchodilatory and antiasthmatic agent.</p> |
