| 摘要 |
NEW MATERIAL:A compound shown by the formulaI[R is H or lower alkanoyl; R<2> is a group shown by the formula II when R<1> is H, and R<2> is H when R<1> is the group shown by the formula II]and its salt. EXAMPLE:8, 8- Bis[1- ( 3, 5-dihydroxyphenoxy )-2, 4, 7, 9-tetrahydroxy-dibenzo-p- dioxine]. USE:A preventive and remedy by adenization exasperation for throbosis. Also useful as an auxiliary for remedies of thrombosis. Having strong suppressing action on plasmin inhibitor activity. PROCESS:For example, Ecklom'a Kurome Okamura is extracted with a solvent such as methanol, etc., concentrated under reduced pressure to give an extract, which is extracted bypartition method between solvents, etc. using ethyl acetate, chloroform, etc., concentrated under reduced pressure, subjected to sellaite column chromatography, etc., and extracted with a solvent such as acetone, etc. to give a compound shown by the formula III (R<2>' is a group shown by the formula IV where R<1>' is H, and R<2>' is H when R<1> is the group shown by the formula IV). |
