7-(THIAZOLYLPROPIONAMIDO) CEPHALOSPORINS, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

This invention relates to cephalosporin derivatives of the formula …… wherein R is hydrogen, a lower alkyl group which may have been substituted, or a carbamoyl group which may have been substituted; R1 is hydrogen or a methoxy group; R2 is hydrogen, an acyloxy group, or a nitrogen-containing 5-membered heterocyclic thio group which may have been substituted; R3 is a free amino group or an amino group having a protective group; and R4 is a free carboxy group or a carboxy group having a protective group; and salts thereof. …Such compounds have shown anti-bacterial activity against gram negative bacteria and against gram positive bacteria and may be formulated in a carrier as pharmaceutical compositions. They are made by reacting the corresponding thiazolylpropionic acid derivatives and 7-amino cephalosporin derivatives.