| 摘要 |
NEW MATERIAL:A compound (salt) shown by the formulaI[R1 is H, 1'-hydroxyethyl, etc.; R2 is a group shown by the formula II(R4 is H or amino-protecting group; n and m are 0-4), formula III (l is 0-2), formula IV(X is H and Y is alkylene, -S-, -SCH2-, vinylene, etc., or X and Y are linded to form -CH=), etc.; R3 is H, or carboxyl-protecting group]. EXAMPLE:(5R, 6S)-2-(4-Piperidinylmethylthio)-6-(CR)-1-hydroxyethyl)penem-3-carboxylic acid. USE:An antibacterial agnet against Gram-positive and Gram-negative bacteria. PROCESS:A triphenylphosphoranilidenemethyl derivative shown by the formula V (R'2 is R, etc.; R3' is R3, etc.; A is O or S; Ph is phenyl) is heated, and, if necessary, is subjected to a proper combination of reactions to remove protecting groups, to give a compound shown by the formulaI. |
