NOVEL QUINOLYLACETIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND

摘要

NEW MATERIAL:The compound of formulaI(R1 is H, lower alkyl, etc.; R2 is H or lower alkyl; R3 is H, halogen, alkyl or alkenyl; R4 and R5 are H, lower alkyl or together form a ring; R6 is H, alkyl, alkenyl, alkynyl, aralkyl, acyl, etc.; A is H or oxo; the dotted line is single or double bond). EXAMPLE:2-(8-Chloro-1,2-dihydro-2,2-dimethylquinolin-6-yl) propionic acid ethyl ester. USE:Antiphlogistic, antipyretic and analgesic agent. PROCESS:The compound of formulaIcan be prepared by reacting the compound of formula II with the compound of formula III (X1 is halogen) in an inert organic solvent in the presence of a tertiary amine (e.g. triethylamine), cuprous chloride and if necessary powdery copper under heating, and thermally cyclizing the resultant compound of formula IV in an inert solvent in the presence of zinc chloride, etc.