| 摘要 |
The invention relates to compounds of the general formula (I> <IMAGE> and physiologically acceptable salts, solvates and hydrates thereof, in which R1 represents hydrogen, C1-14 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, trifluoroalkyl, heteroaralkyl or alkyl substituted by cycloalkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino; and R2 represents hydrogen or a C1-4 alkyl group; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom selected from oxygen or sulphur; Alk represents a straight or branched alkylene chain or 1 to 3 carbon atoms; Q represents a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions; R5 represents hydrogen or acyl; n and m, which may be the same or different, are each 1 or 2; R3 represents hydrogen or alkyl; R4 represents hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, pyridyl, aralkyl, heteroaralkyl or alkyl substituted by hydroxy, C1-3 alkoxy, amino C1-3 alkylamino or C1-3 dialkylamino, or R3 and R4 together with the nitrogen atom to which they are attached form a 5-7 membered ring which may contain another heteroatom; and r represents an integer which is 1 or 2. The compounds of formula (I) show biological activity as selective histamine H2-antagonists. |
