Novel derivatives of bicyclic amino acids, process for their preparation, compositions containing them and their use, and also novel bicyclic amino acids as intermediates and process for their preparation

摘要

The invention relates to cis, exo- and trans-compounds of the formula I <IMAGE> in which n denotes 0, 1 or 2, R1 denotes hydrogen, alkyl which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which in each case can be substituted by alkyl, alkoxy or halogen, arylalkyl which can be substituted in the aryl radical as defined above, a mono- or bicyclic S- or O- and/or N-heterocycle radical or a side chain of a naturally occurring amino acid, R2 denotes hydrogen, alkyl, alkenyl or arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl which can be mono-, di- or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, and their physiologically acceptable salts, a process for their preparation, compositions containing them and their use, and also novel bicyclic amino acids as intermediates and a process for their preparation.