| 摘要 |
PURPOSE:To obtain a carrier for serodiagnosis, etc. which can be preserved for a long period of time and has excellent characteristics by contg. anionic or nonionic surfactants in an aq. soln. of gelatin, water soluble polysaccharides and sodium polymetaphosphate prior to controlling of said soln. to a specific pH range. CONSTITUTION:An aq. soln. of gelatin, water soluble polysaccharides such as gum arabic and sodium polymetaphosphosphate (in other words, only water is used, without making combination use of org. solvents) is maintained at temp. higher than the gelling temp. of the gelatin and a soln. of anionic or nonionic surfactants are added thereto; thereafter a soln. of acetic acid, etc. is dropped to the soln. under stirring to adjust 2.5-6.0pH and to form particles. According to the conditions such as pH and compsns. of raw materials, grain sizes can be controlled to desired values. After the formation of the particles, the soln. is cooled and when the temp. drops to <=10 deg.C, aldehyde crosslinking agents are added to the soln. to insolubilize the same. The particles are centrifugally sepa rated and washed, whereby the carrier is obtained. This carrier is obtainable in good yields and with uniform properties, and is preservable for a long period of time. The carrier bound with antigens or antibodies is stable without liberation of the antigens, etc. even when preserved by freeze drying. |
