| 摘要 |
PURPOSE:To obtain a carrier suited for serodiagnosis, etc. by contg. anionic or nonionic surfactants into a soln. contg. gelatin, water soluble polysaccharides, sodium polymetaphosphate as well as a hydrophilic org. solvent and water prior to adjusting of said soln. to a specific pH range. CONSTITUTION:Prior to adjusting of a soln. contg. gelatin, water soluble polysaccharides such as gum arabic, sodium polymetaphosphate (NaPO3)n, a hydrophilic org. solvent such as lower alcohol or aceton, and water to 2.5-6.0pH by adding acids under stirring at temp. higher than the gelling temp. of the gelatin, a soln. of anionic or nonionic surfactants is added thereto, then acids such as acetic acid soln. are added thereto to form gel particles. A particle dispersion is cooled and when the temp. thereof drops to <=10 deg.C, aldehyde crosslinking agents (glutaraldehyde, H2CO, etc.) are added to the soln. to obtain crosslinked gells. Thus, optional grain sizes can be provided to the carrier, and the homogeneous and stable carriers is obtained in good yields. The carrier bound with antigens or antibodies retains the initial characteristics without deterioration even when frozen abd preserved for a long period of time. |
