METODO PARA SEPARAR EL FACTOR ESPECIFICO VIII DE COAGULACION DE LA SANGRE A PARTIR DE SU MEZCLA CON OTRAS PROTEINAS DE LA SANGRE

摘要

The invention relates to polyelectrolytes and their use in the separation of blood proteins. …Blood coagulation factors such as Factor VIII are separated from admixture with other blood proteins without producing activation of said coagulation factor by contacting with a water-insoluble, cross-linked polyelectrolyte copolymer of (a) C2-18 unsaturated monomer and (b) C4-12 unsaturated polycarboxylic acid or anhydride, in which 2-100% of the carboxyl sites are substituted with amineimides and substantially all the free anhydrides are blocked with alkoxyalkylamine to form alkoxyalkylimide units.