Derivatives with a uronic acid structure, their preparation and their biological applications.

摘要

1. Derivatives possessing a uronic acid structure, characterised in that they correspond to formula III : see diagramm : EP0082793,P28,F1 in which R1 represents a reactive group selected from . a halide, preferably a chloride or a bromide . a -O-imidoyl group, or . together with the adjacent -OR2 substituant, an orthoester group, or again . a -O-alkenyl group, preferably -O-allyl, or . an OH group which is free or is blocked by a protective grouping selected from the aliphatic or aromatic radicals, in particular in the group comprising an alkyl radical containing from 1 to 4 carbon atoms such as methyl, a substituted alkyl radical such as benzyl, an acyl such as acetyl, benzoyl or chloroacetyl, or an alkenyl radical containing from 1 to 4 carbon atoms such as allyl or vinyl, assuming that, when R1 represents a methoxy group, OR4 is different from such a group, R2 , R3 and R4 , the three of which cannot all be identical in the case of glucuronic derivatives, R3 and R4 also being different from an acetyl group when R1 and R2 together form an orthoester, R2 and R3 being different from a benzyl group when R1 represents a chlorine atom and R4 represents a methyl group, or when R1 represents a -O-alkyl group and R4 a hydrogen atom, represent . an alkenyl group, preferably an allyl group, . a hydrogen atom or . an OH group blocked by a protective grouping as defined above for R1 , R6 represents a hydrogen atom or a protective group as defined above, or the salts of these derivatives, with the exclusion of iduronic acid derivatives in which R1 , R2 and R3 all represent a benzyl group and R6 represents a methyl group.