Novel ergolinyl compounds nitrogen-substituted in the 8-position, their preparation, and use as medicinal agents.

摘要

Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) <CHEM> and physiologically compatible salts thereof, wherein (a) R<1> is hydrogen, the 8-substituent can be in the alpha - or beta -position and <CHEM> represents a single or double bond. R<2> is hydrogen, C1 4-alkyl or C1 7-acyl, R<3> is hydrogen, chlorine or bromine, and R<4> is C1-6-alkyl, C3-6-cycloalkyl-C1-3-alkyl, C3 6-alkenyl, or C3-6-alkynyl; or (b) R<1> is -@-NR<5>R<6>, and the 8-substituent can be in the alpha - or beta -position, <CHEM> represents a single or double bond, R<2>, R<3> are as defined above, R<4>, is C1-6-alkyl, C3-6-cycloalkyl-C1-3-alkyl, C3-6-alkenyl, or C3-6-alkynyl; and R<5> is hydrogen, C1-10-alkyl, C3 10-alkenyl, or C3 10-alkynyl, and R<6> is C1-10-alkyl, C3-10-alkenyl, C3-10-alkynyl, or aryl, or R<5> and R<6> together with the connecting N-atom form a 5- to 10-membered heterocyclic ring, preferably 5- or 6-membered, which optionally can contain further heteroatoms.