THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

摘要

Compounds of the formula: …… wherein… R<1>, which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);… Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;… X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;… and… R, which is attached to carbon atom of ring "B", is a group of the formula: …… where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;… and the pharmaceutically, acceptable salts thereof. …The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.