| 摘要 |
Cephalosporin antibiotics of general formula <IMAGE> (wherein R represents a 3- or 4-carbamoyl group or a hydrogen atom) and non-toxic salts and non-toxic metabolically labile esters thereof. The compounds exhibit broad spectrum antibiotic activity and have high activity against both Gram-positive and Gram-negative organisms, including many b-lactamase producing strains. Especially preferred are those compounds in which R is hydrogen. Acid intermediates of formula <IMAGE> (wherein R<2> is amine or protected amine) are also disclosed. |
