| 摘要 |
PURPOSE:To provide an antiphlogistic and analgesic ointment having excellent transcutaneous absorptivity and antiphlogistic and analgesic activities, and having no side effects inherent to the oral administration, by using ketoprofen as an active component in combination with an emulsion base composed of higher alcohol, hydrocarbons, water, and emulsifying agent. CONSTITUTION:The objective antiphlogistic and analgesic ointment contains 0.5-5wt% ketoprofen of formula, 5-15wt% higher alcohol (e.g. stearyl alcohol), 10-20wt% hydrocarbons (e.g. white petrolatum, 51.5-82.4wt% water, 1-3wt% emulsifying agent (e.g. polyoxyethylene alkyl ether), and 0.1-0.5wt% preservative (e.g. p-oxybenzoic acid ester). Ketoprofen is known as a drug for oral administration, and its side effects such as gastroenteric, hepatic and renal disorders caused by the continuous oral administuration can be prevented by using the compound as external agent. The above ointment may be incorporated with absorption acclerating agent, moisture retaining agent, etc., and is preservable for a long period. |
