| 摘要 |
<p>3-B-A-NH-N- (2-(5-dimethylaminomethyl- furan-2-yl-methylthio) ethyl)- benzamide derivs. of formula (III) and their salts are new (where A is CO or SO2 and B is 1-6C alkyl, phenyl, pyridyl, pyridyl-1-oxide, pyrazinyl or thienyl). Histamine H2 receptor antagonists, which inhibit gastric secretion and are used to treat ulcers. Activity tests show that many of the cpds. have better gastric H2 blocking activity than does cimetidine or rasitidine, whereas their cardiac H2 blocking activity is much weaker. (III) may be administered enterally or parenterally in doses of 1-100, pref. 10-50, mg/Kg/ day. Adult doses comprise 10-100, pref. 100-500, mg. (III) where B-A is methanesulphonyl, ethanesulphonyl, butanesulphonyl, benzenesulphonyl or 2-thiophenecarbonyl and their salts.</p> |
