A METHOD OF OBTAINING OPTICALLY ACTIVE, AT A GIVEN TIME SUBSTITUTED 2- AMINO- 2- PHENYL ACETIC ACID

摘要

Optically active 2-amino-2-phenylacetic acid of the formula in which R1, R2 and R3, which are identical or different, denote hydrogen, halogen, hydroxy, alkyl, acyl, or alkoxy, is prepared by asymmetrical transformation of a corresponding DL-aminophenylacetonitrile with L(+)-tartaric acid. To this end the corresponding DL-2-amino-2-phenyl-acetonitrile is reacted with approximately equimolar amounts of L(+)-tartaric acid in the presence of at least one alkanol having from 1 to 5 carbon atoms and/or at least one carbonyl compound at a temperature of from 0 DEG to 50 DEG C. and the mixture is stirred for 2 to 120 hours at the indicated temperature. The crystallized transformation product is separated, hydrolyzed by treatment with an acid and the desired product is isolated.