发明名称 |
DIPYRIDAMOL SUSTAINED RELEASE FORMS AND PROCESSES FOR THE PREPARATION THEREOF |
摘要 |
A dipyridamole sustained release formulation comprises a plurality of spheroidal particles, each of the said spheroidal particles comprising: (a) a core containing dipyridamole or a crystallised salt thereof and a physiologically compatible acid substance in a ratio of at least 1 equivalent of acid substance to 1 mol of dipyridamole or crystallised salt thereof; and (b) a coating which surrounds the core, the coating comprising from 50 to 100% by weight of acid-insoluble lacquer soluble in intestinal juices and from 0 to 50% by weight of lacquer insoluble in gastric and intestinal juices, with the proviso that where the lacquer insoluble in gastric and intestinal juices comprises ethyl cellulose, the weight of ethyl cellulose present does not exceed 14% of the total weight of the coating. |
申请公布号 |
CA1148084(A) |
申请公布日期 |
1983.06.14 |
申请号 |
CA19810368242 |
申请日期 |
1981.01.09 |
申请人 |
THOMAE (DR. KARL) G.M.B.H. |
发明人 |
GRUBER, PETER;BRICKL, ROLF;BOZLER, GERHARD;STRICKER, HERBERT |
分类号 |
A61K9/16;A61K9/22;A61K9/24;A61K9/48;A61K9/50;A61K9/52;A61K9/54;A61K9/56;A61K31/505;A61P9/08;A61P9/10 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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