发明名称 |
Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates |
摘要 |
A complex of polyriboinosinic-polyribocytidylic acid (poly I:C) with poly-L-lysine hydrobromide ([lysine.HBr]n) having a defined molecular weight is prepared which is about 5-15 times as resistant to hydrolysis by pancreatic ribonuclease as the parent poly I:C. A pharmaceutical solution, containing a relatively high concentration of the complex, prepared as described, induces significant antiviral levels of serum interferon in monkeys under conditions in which poly I:C itself induces little or no interferon. An important feature of this invention is that the product is a soluble material requiring no special solubilizing agent, thereby facilitating the preparation of solutions having the desired concentration. The product will hereinafter be designated as poly I:C/poly-L-lysine.
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申请公布号 |
US4388306(A) |
申请公布日期 |
1983.06.14 |
申请号 |
US19820346673 |
申请日期 |
1982.02.08 |
申请人 |
MERCK & CO., INC. |
发明人 |
FIELD, A. KIRK;TYTELL, ALFRED A.;LAMPSON, GEORGE P. |
分类号 |
A61K31/785;C07H21/00;(IPC1-7):A61K37/02;A61K45/02 |
主分类号 |
A61K31/785 |
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